Heavy Cannabis

The NAP report highlights the following findings on the issue of cancer:

The evidence suggests that smoking cannabis does not increase the risk for certain cancers (i.e., lung, head and neck) in adults.

There is modest evidence that cannabis use is associated with one subtype of testicular cancer.

There is minimal evidence that parental cannabis use during pregnancy is associated with greater cancer risk in offspring.

RESPIRATORY DISEASE

The NAP report highlights the following findings on the issue of respiratory diseases:

Smoking cannabis on a regular basis is associated with chronic cough and phlegm production.

Quitting cannabis smoking is likely to reduce chronic cough and phlegm production.

It is unclear whether cannabis use is associated with chronic obstructive pulmonary disorder, asthma, or worsened lung function.

IMMUNE SYSTEM

The NAP report highlights the following findings on the issue of the human immune system:

There exists a paucity of data on the effects of cannabis or cannabinoid-based therapeutics on the human immune system.

There is insufficient data to draw overarching conclusions concerning the effects of cannabis smoke or cannabinoids on immune competence.

There is limited evidence to suggest that regular exposure to cannabis smoke may have anti-inflammatory activity.

There is insufficient evidence to support or refute a statistical association between cannabis or cannabinoid use and adverse effects on immune status in individuals with HIV.

MORTALITY

The NAP report highlights the following findings on the issue of the increased risk of death or injury:

Cannabis use prior to driving increases the risk of being involved in a motor vehicle accident.

In states where cannabis use is legal, there is increased risk of unintentional cannabis overdose injuries among children.

It is unclear whether and how cannabis use is associated with all-cause mortality or with occupational injury.

BRAIN FUNCTION

The NAP report highlights the following findings on the issue of cognitive performance and mental health:

Recent cannabis use impairs the performance in cognitive domains of learning, memory, and attention. Recent use may be defined as cannabis use within 24 hours of evaluation.

A limited number of studies suggest that there are impairments in cognitive domains of learning, memory, and attention in individuals who have stopped smoking cannabis.

Cannabis use during adolescence is related to impairments in subsequent academic achievement and education, employment and income, and social relationships and social roles.

Cannabis use is likely to increase the risk of developing schizophrenia and other psychoses; the higher the use, the greater the risk.

In individuals with schizophrenia and other psychoses, a history of cannabis use may be linked to better performance on learning and memory tasks.

Cannabis use does not appear to increase the likelihood of developing depression, anxiety, and posttraumatic stress disorder.

For individuals diagnosed with bipolar disorders, near daily cannabis use may be linked to greater symptoms of bipolar disorder than for nonusers.

Heavy cannabis users are more likely to report thoughts of suicide than are nonusers.

Regular cannabis use is likely to increase the risk for developing social anxiety disorder.

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